Harpagophytum procumbens, also called grapple plant, wood spider and most commonly Devil's Claw, is a plant of the sesame family, native to South Africa. It got its name from the peculiar appearance of its hooked fruit. The plant's large tuberous roots are used medicinally to reduce pain and fever, and to stimulate digestion. European colonists brought Devil's Claw home where it was used to treat arthritis.

H. procumbens are mainly found in the eastern and south eastern parts of Namibia, Southern Botswana and the Kalahari region of the Northern Cape, South Africa. H. Zeyheri is found in the northern parts of Namibia (Ovamboland) and southern Angola. The active ingredient is harpagoside (structure at PubChem [1]) with values ranging in both species from 1.0% to 3.3%.

The name "devil's claw" is also used for several species of North American plants in the genus Proboscidea, as well as Urtica dioica.